Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside Document date: 2016_9_20
ID: 04pp3lv0_75
Snippet: Another downstream mediator of TGF-β is amphiregulin (AR), which is an epidermal growth factor receptor (EGFR) ligand primarily induced by TGF-β1 [228] . siRNAs targeting AR and CTGF were delivered to the lung of pulmonary fibrosis mouse model via either intratracheal or intravenous administration. To improve the efficiency and cell-specific delivery, a modified self-assembled micelle interfering RNA nanoparticles (SAMiRNA) was developed. The n.....
Document: Another downstream mediator of TGF-β is amphiregulin (AR), which is an epidermal growth factor receptor (EGFR) ligand primarily induced by TGF-β1 [228] . siRNAs targeting AR and CTGF were delivered to the lung of pulmonary fibrosis mouse model via either intratracheal or intravenous administration. To improve the efficiency and cell-specific delivery, a modified self-assembled micelle interfering RNA nanoparticles (SAMiRNA) was developed. The nanoparticles contain hydrophilic polymer and hydrophobic lipid on each ends of siRNA and can spontaneously form micelle in solution. After administration of AR or CTGF SAMiRNAs, the expression of AR and CTGF, and collagen accumulation in the lung of pulmonary fibrosis model were significantly reduced compared to control SAMiRNA [8] .
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