Author: Chernobrovkin, Alexey L.; Zubarev, Roman A.
Title: Detection of Viral Proteins in Human Cells Lines by Xeno-Proteomics: Elimination of the Last Valid Excuse for Not Testing Every Cellular Proteome Dataset for Viral Proteins Document date: 2014_3_11
ID: 0hrwqho8_27
Snippet: The proteomes of the remaining 10 cell lines studied by Geiger et al. were interrogated. In the LNCaP cell line, we found two viral proteins belonging to the XMRV virus. The envelope glycoprotein (ENV_XMRV4) and Gag-Pol polyprotein (POL_XMRV4) compose full proteome of that virus (Table S3 ). The observed peptides represented a relatively low coverage of proteins sequences (13% and 25%, respectively), but were distributed along the whole protein s.....
Document: The proteomes of the remaining 10 cell lines studied by Geiger et al. were interrogated. In the LNCaP cell line, we found two viral proteins belonging to the XMRV virus. The envelope glycoprotein (ENV_XMRV4) and Gag-Pol polyprotein (POL_XMRV4) compose full proteome of that virus (Table S3 ). The observed peptides represented a relatively low coverage of proteins sequences (13% and 25%, respectively), but were distributed along the whole protein sequence (Figure 2) , indicating likely expression of fully functional viral polypeptides.
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