Author: Patton, John B.; Bennuru, Sasisekhar; Eberhard, Mark L.; Hess, Jessica A.; Torigian, April; Lustigman, Sara; Nutman, Thomas B.; Abraham, David
Title: Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum Document date: 2018_12_12
ID: 0yh5k6jk_58
Snippet: It was of interest to note that the immune response found in normal mice was highly efficient at eliminating the L3 of O. volvulus, but the human immune cells in NSG mice were supportive rather than destructive of the parasites. It is possible that the mouse immune cells were evolutionally adapted to eliminate the parasites, whereas the human cells were evolutionally adapted to support the parasites as observed in nature. A comparison between mou.....
Document: It was of interest to note that the immune response found in normal mice was highly efficient at eliminating the L3 of O. volvulus, but the human immune cells in NSG mice were supportive rather than destructive of the parasites. It is possible that the mouse immune cells were evolutionally adapted to eliminate the parasites, whereas the human cells were evolutionally adapted to support the parasites as observed in nature. A comparison between mouse and human immune reactions to the worms might yield important new insights into the etiology of resistance and susceptibility to infection with O. volvulus.
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