Author: Shrestha, Ashish C.; Wijesundara, Danushka K.; Masavuli, Makutiro G.; Mekonnen, Zelalem A.; Gowans, Eric J.; Grubor-Bauk, Branka
Title: Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines Document date: 2019_4_30
ID: 141u6ax7_16
Snippet: tic Protein rin (PRF) is a pore forming protein released by immune cells including NK cells and T lymphocytes (CTL) [91] . The 67-kilodalton PRF protein oligomerizes to form pores that channel to release granzyme into the cytosol of target cells [92] . Suicide genes inducing of target cells have been used for cancer therapies, and the role of apoptotic cell death in n, whether immune-stimulatory or immune-suppressive, is debated [93] . Recently, .....
Document: tic Protein rin (PRF) is a pore forming protein released by immune cells including NK cells and T lymphocytes (CTL) [91] . The 67-kilodalton PRF protein oligomerizes to form pores that channel to release granzyme into the cytosol of target cells [92] . Suicide genes inducing of target cells have been used for cancer therapies, and the role of apoptotic cell death in n, whether immune-stimulatory or immune-suppressive, is debated [93] . Recently, a novel hnology has been developed--termed cytolytic DNA technology-in which a truncated F is incorporated in a bicistronic DNA vector to act as a vaccine adjuvant [55] [56] [57] 94] .
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