Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside Document date: 2016_9_20
ID: 04pp3lv0_44
Snippet: Another study reported the administration of siRNA targeting NP and/or PA in lipid carrier to influenza-infected mice by hydrodynamic injection and intranasal administration. The combined siRNA delivery method effectively protected animals against lethal challenge of highly pathogenic avian influenza A viruses, including the H5N1, H7N7 and H9N2 subtypes [126] . Since then, the potential of siRNA for the treatment of influenza virus infection was .....
Document: Another study reported the administration of siRNA targeting NP and/or PA in lipid carrier to influenza-infected mice by hydrodynamic injection and intranasal administration. The combined siRNA delivery method effectively protected animals against lethal challenge of highly pathogenic avian influenza A viruses, including the H5N1, H7N7 and H9N2 subtypes [126] . Since then, the potential of siRNA for the treatment of influenza virus infection was continuously evaluated in vitro [133, [147] [148] [149] and in vivo [127] [128] [129] . However, the exploration of RNAi for the treatment of influenza appears to reach the bottleneck. It could be partly attributed to the criticism of the antiviral effect induced by siRNA, which was due to innate immune response rather than viral inhibition through RNAi. Development of chemically modified RNAi molecules with minimal immunostimulatory effect could be helpful to delineate the mechanism of the antiviral effects [150] .
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