Selected article for: "protein sequence and sequence conservation"
Author: Brandon Malone; Boris Simovski; Clement Moline; Jun Cheng; Marius Gheorghe; Hugues Fontenelle; Ioannis Vardaxis; Simen Tennoe; Jenny-Ann Malmberg; Richard Stratford; Trevor Clancy
Title: Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2: toward universal blueprints for vaccine designs
  • Document date: 2020_4_21
    • ID: cm30gyd8_31
    Snippet: Although the identified hotspots seem to be maintained across different viral strains, in order to design the most robust vaccine blueprint that will hopefully provide broad protection against new emerging clades of the SARS-COV-2 virus, the epitope hotspots were subject to a sequence conservation analysis. The goal of this analysis was to identify hotspots that appear to be less prone to mutation across thousands of viral sequences. We calculate.....
    Document: Although the identified hotspots seem to be maintained across different viral strains, in order to design the most robust vaccine blueprint that will hopefully provide broad protection against new emerging clades of the SARS-COV-2 virus, the epitope hotspots were subject to a sequence conservation analysis. The goal of this analysis was to identify hotspots that appear to be less prone to mutation across thousands of viral sequences. We calculated a conservation score for each hotspot based on the consensus sequence of a protein (see Materials and

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