Author: Shields, Lauren E.; Jennings, Jordan; Liu, Qinfang; Lee, Jinhwa; Ma, Wenjun; Blecha, Frank; Miller, Laura C.; Sang, Yongming
Title: Cross-Species Genome-Wide Analysis Reveals Molecular and Functional Diversity of the Unconventional Interferon-? Subtype Document date: 2019_6_25
ID: 14gcu1se_30
Snippet: The archetypal subtypes of type I IFNs in mammals such as IFN-β, -ε, and -κ, appear ramified in reptiles, and IFN-α and -ω subtypes were remarkable in birds with some ambiguous progenitors detected in reptiles, as well (Supplemental Excel Sheet 2) (2, 12) . In contrast, the gene composition of type III IFNs (i.e., IFN-λs) was ramified and expanded in amphibians; however it was reduced dramatically in reptiles and birds (generally only one I.....
Document: The archetypal subtypes of type I IFNs in mammals such as IFN-β, -ε, and -κ, appear ramified in reptiles, and IFN-α and -ω subtypes were remarkable in birds with some ambiguous progenitors detected in reptiles, as well (Supplemental Excel Sheet 2) (2, 12) . In contrast, the gene composition of type III IFNs (i.e., IFN-λs) was ramified and expanded in amphibians; however it was reduced dramatically in reptiles and birds (generally only one IFN-λ gene) and remained relatively stable (generally 3-5) in different mammalian clades/species (5, 9) . In addition, typical intronless IFN-λ genes were only determined in amphibian species, and rarely determined in mammalian species except a bat species (Myotis brandtii) (Supplemental Excel Sheet 2 and Data not shown).
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