Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox Document date: 2012_3_1
ID: 0mmtcbof_12
Snippet: Altogether, these results indicate that early local immune responses induced after in vivo MVA inoculation are characterized by powerful innate responses, including the migration of massive amounts of innate immune cells to the site of infection. Moreover, antigen-specific cellular and humoral immune responses were also rapidly induced within the respiratory tract, suggesting that the rapid protection provided by MVA may be due to a close interpl.....
Document: Altogether, these results indicate that early local immune responses induced after in vivo MVA inoculation are characterized by powerful innate responses, including the migration of massive amounts of innate immune cells to the site of infection. Moreover, antigen-specific cellular and humoral immune responses were also rapidly induced within the respiratory tract, suggesting that the rapid protection provided by MVA may be due to a close interplay between innate and adaptive immunity.
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