Selected article for: "facs analysis and NK cell"
Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox
  • Document date: 2012_3_1
    • ID: 0mmtcbof_16
    Snippet: NK cells are known to play a major role in mediating resistance to ECTV infections in mice [50] [51] [52] and indeed, we found NK cells infiltrating the lungs of mice early after i.n. MVA inoculation ( Figure S3D ). To examine the role of NK cells in rapid protection we removed NK cells by antibody-mediated depletion. Absence of NK cells on the day of MVA immunization (day -2) was confirmed by FACS analysis ( Figure S6A ). We observed no differen.....
    Document: NK cells are known to play a major role in mediating resistance to ECTV infections in mice [50] [51] [52] and indeed, we found NK cells infiltrating the lungs of mice early after i.n. MVA inoculation ( Figure S3D ). To examine the role of NK cells in rapid protection we removed NK cells by antibody-mediated depletion. Absence of NK cells on the day of MVA immunization (day -2) was confirmed by FACS analysis ( Figure S6A ). We observed no difference in the protective capacity acquired by NK cell-depleted mice compared to controls ( Figure 2D ; P = 1), indicating that the protective effect of short-term immunization with MVA is fully maintained even in the absence of NK cells.

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