Author: Yuan, Yuan; Cao, Duanfang; Zhang, Yanfang; Ma, Jun; Qi, Jianxun; Wang, Qihui; Lu, Guangwen; Wu, Ying; Yan, Jinghua; Shi, Yi; Zhang, Xinzheng; Gao, George F.
Title: Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Document date: 2017_4_10
ID: 094lgjnn_3
Snippet: Here we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy (cryo-EM). We captured two states of the RBD that is facilitated to receptor binding and further analysis of S proteins revealed the potential targets for eliciting broadly neutralizing antibodies......
Document: Here we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy (cryo-EM). We captured two states of the RBD that is facilitated to receptor binding and further analysis of S proteins revealed the potential targets for eliciting broadly neutralizing antibodies.
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