Author: Hayward, Joshua A; Tachedjian, Mary; Cui, Jie; Cheng, Adam Z; Johnson, Adam; Baker, Michelle L; Harris, Reuben S; Wang, Lin-Fa; Tachedjian, Gilda
Title: Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity Document date: 2018_3_29
ID: 1i6c0l3e_12
Snippet: Analysis of the phylogenetic relationships between the A3 proteins of P. alecto and other mammals ( fig. 2 ) confirms the expected phylogenetic positions of the A3Z1, A3Z2A, and A3Z3 proteins, and reveals that the A3Z2B proteins, containing both Z1-and Z2-defining sequence motifs, phylogenetically cluster within the broader A3Z2 clade. Notably, pteropid A3Z2A and A3Z2B are positioned a greater sequence distance from each other than from the A3Z2 .....
Document: Analysis of the phylogenetic relationships between the A3 proteins of P. alecto and other mammals ( fig. 2 ) confirms the expected phylogenetic positions of the A3Z1, A3Z2A, and A3Z3 proteins, and reveals that the A3Z2B proteins, containing both Z1-and Z2-defining sequence motifs, phylogenetically cluster within the broader A3Z2 clade. Notably, pteropid A3Z2A and A3Z2B are positioned a greater sequence distance from each other than from the A3Z2 proteins of distantly related mammals, revealing that pteropid bats possess four phylogenetically distinct A3 Z-domain subtypes, two of which appear to be derivatives of the Z2 clade.
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