Author: Selinger, Christian; Tisoncik-Go, Jennifer; Menachery, Vineet D; Agnihothram, Sudhakar; Law, G Lynn; Chang, Jean; Kelly, Sara M; Sova, Pavel; Baric, Ralph S; Katze, Michael G
Title: Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates Document date: 2014_12_22
ID: 0y3m47lh_3
Snippet: A functional genomics approach revealed MERS-CoV and infectious clone SARS-CoV (icSARS-CoV) activated expression of pathogen recognition receptor genes and pro-inflammatory cytokine genes related to interleukin 17 (IL-17) signaling by IL-17A and IL-17 F cytokines, while differentially regulating antigen presentation pathway gene expression [11] . The human immune response to MERS-CoV appears to be distinct across patients, with increased secretio.....
Document: A functional genomics approach revealed MERS-CoV and infectious clone SARS-CoV (icSARS-CoV) activated expression of pathogen recognition receptor genes and pro-inflammatory cytokine genes related to interleukin 17 (IL-17) signaling by IL-17A and IL-17 F cytokines, while differentially regulating antigen presentation pathway gene expression [11] . The human immune response to MERS-CoV appears to be distinct across patients, with increased secretion of IL-17A and IL-23 in bronchoalveolar lavage (BAL) supernatants and increased CXCL10 in serum of patients infected with MERS-CoV [12] . The patient with the poor outcome showed decreased expression of innate immune genes, such as DDX58, IFIH1 (encoding MDA5), IRF3, IRF7, IFNA, and IFNB1, which may be the result of host and virus-specific genetic differences. Recent phylogenetic analyses of the complete viral genome from 21 different MERS cases demonstrate the extent of adaptive changes in MERS-CoV since the initial outbreak [13] .
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