Author: Patton, John B.; Bennuru, Sasisekhar; Eberhard, Mark L.; Hess, Jessica A.; Torigian, April; Lustigman, Sara; Nutman, Thomas B.; Abraham, David
Title: Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum Document date: 2018_12_12
ID: 0yh5k6jk_55
Snippet: The present study did not identify the point at which O. volvulus ceased surviving and developing in NSG mice. Studies with the human parasite S. stercoralis have demonstrated that the entire parasite life cycle will develop in NSG mice within 4-weeks [31] . Given the significant difference in time that it takes for O. volvulus adults to develop (12-15 months in chimpanzees [9, 10] ) and their size as mature adults (females are 50 cm [68] ) it is.....
Document: The present study did not identify the point at which O. volvulus ceased surviving and developing in NSG mice. Studies with the human parasite S. stercoralis have demonstrated that the entire parasite life cycle will develop in NSG mice within 4-weeks [31] . Given the significant difference in time that it takes for O. volvulus adults to develop (12-15 months in chimpanzees [9, 10] ) and their size as mature adults (females are 50 cm [68] ) it is unlikely that the entire O. volvulus life cycle, including mating and development of microfilariae, will occur in NSG mice.
Search related documents:
Co phrase search for related documents- present study and significant difference: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- present study and time significant difference: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- significant difference and time significant difference: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- significant difference and volvulus adult: 1
Co phrase search for related documents, hyperlinks ordered by date