Author: Hayward, Joshua A; Tachedjian, Mary; Cui, Jie; Cheng, Adam Z; Johnson, Adam; Baker, Michelle L; Harris, Reuben S; Wang, Lin-Fa; Tachedjian, Gilda
Title: Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity Document date: 2018_3_29
ID: 1i6c0l3e_4
Snippet: In this study, pteropid A3 loci were generated through the step-wise extension of cDNA-mapped gene scaffolds followed by remapping of sequence read archives, supported experimentally by an A3 expression analysis of bat spleen tissue. The functionality of P. alecto A3 subtypes were investigated through analysis of their ability to deaminate DNA, and restrict the infectivity of a model retrovirus. The role of A3mediated restriction of ancient bat r.....
Document: In this study, pteropid A3 loci were generated through the step-wise extension of cDNA-mapped gene scaffolds followed by remapping of sequence read archives, supported experimentally by an A3 expression analysis of bat spleen tissue. The functionality of P. alecto A3 subtypes were investigated through analysis of their ability to deaminate DNA, and restrict the infectivity of a model retrovirus. The role of A3mediated restriction of ancient bat retroviruses was assessed using a hypermutation analysis of endogenous retroviruses within the genome of P. vampyrus.
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