Author: Hao, Wei; Wojdyla, Justyna Aleksandra; Zhao, Rong; Han, Ruiyun; Das, Rajat; Zlatev, Ivan; Manoharan, Muthiah; Wang, Meitian; Cui, Sheng
Title: Crystal structure of Middle East respiratory syndrome coronavirus helicase Document date: 2017_6_26
ID: 0vxhgjss_4
Snippet: MERS-CoV is a member of Coronaviridae family, one of the four distantly related virus families (the other three are Arteriviridae, Mesoniviridae and Roniviridae) in Nidovirales order [4] [5] [6] . This monophyletic group of viruses includes the largest known RNA genomes in families Roniviridae (~26 kb) and Coronaviridae (from 26.3 to 31.7 kb), as well as, small-sized Arteriviridae (12.7 to 15.7 kb) and medium-sized Mesoniviridae (20.2 kb) [7, 8] .....
Document: MERS-CoV is a member of Coronaviridae family, one of the four distantly related virus families (the other three are Arteriviridae, Mesoniviridae and Roniviridae) in Nidovirales order [4] [5] [6] . This monophyletic group of viruses includes the largest known RNA genomes in families Roniviridae (~26 kb) and Coronaviridae (from 26.3 to 31.7 kb), as well as, small-sized Arteriviridae (12.7 to 15.7 kb) and medium-sized Mesoniviridae (20.2 kb) [7, 8] . Coronaviridae family is divided into Torovirinae and Coronavirinae subfamilies, with the latter consisting of α-CoVs, β-CoVs, δ-CoVs and γ-CoV genera [5] . Six human CoVs have been identified to date, including α-CoVs 229E-CoV and NL63-CoV and β-CoVs OC43-CoV and HKU1-CoV from lineage A, SARS-CoV from lineage B and MERS-CoV from lineage C [9] [10] [11] .
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