Author: Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea
Title: Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers Document date: 2019_12_25
ID: 034w5afv_1
Snippet: Nitazoxanide (NTZ), 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide, is a synthetic nitrothiazole derivative (Scheme 1) with a broad spectrum of applications as an antiparasitic, antibacterial and antiviral agent, being effective against protozoal infections, helminths, gram negative and gram positive bacteria, and diverse viruses (respiratory viruses, rotavirus, norovirus, coronavirus, hepatitis B and C, dengue-2, yellow fever, Japanese encephaliti.....
Document: Nitazoxanide (NTZ), 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide, is a synthetic nitrothiazole derivative (Scheme 1) with a broad spectrum of applications as an antiparasitic, antibacterial and antiviral agent, being effective against protozoal infections, helminths, gram negative and gram positive bacteria, and diverse viruses (respiratory viruses, rotavirus, norovirus, coronavirus, hepatitis B and C, dengue-2, yellow fever, Japanese encephalitis, and human immunodeficiency viruses) [1] [2] [3] . Moreover, NTZ has shown anticancer activity [4] , suppresses the production of interleukins (IL) such as IL-6 [5] , and is a promising compound for the treatment of neuropathic pain and the Ebola virus disease [6, 7] .
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