Author: Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea
Title: Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers Document date: 2019_12_25
ID: 034w5afv_56
Snippet: The results presented herein have shown that NTZ cocrystals can induce a superior dissolution behavior in the presence of hydroxypropyl methylcellulose (HMPC) and methylcellulose (Methocel ® 60 HG) in comparison to pure NTZ. Although rapid transformation to the less soluble drug form is observed, the inclusion of polymer in the formulations with NTZ-SUC cocrystals in amounts of 2.5 and 5.0% (w/w) enabled significantly increasing the dissolution .....
Document: The results presented herein have shown that NTZ cocrystals can induce a superior dissolution behavior in the presence of hydroxypropyl methylcellulose (HMPC) and methylcellulose (Methocel ® 60 HG) in comparison to pure NTZ. Although rapid transformation to the less soluble drug form is observed, the inclusion of polymer in the formulations with NTZ-SUC cocrystals in amounts of 2.5 and 5.0% (w/w) enabled significantly increasing the dissolution rate of NTZ when compared to pure NTZ and the commercially available drug formulation. The comparative analysis of different powder formulations showed that the amount of polymer in the formulation is an important parameter to consider during cocrystal formulation development for accessing a good solubilization potential for poorly soluble APIs in aqueous solutions.
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