Author: Qing, Enya; Hantak, Michael; Perlman, Stanley; Gallagher, Tom
Title: Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection Document date: 2020_2_11
ID: 1mowsbjy_5
Snippet: Surprisingly, VLP binding to cells was not increased by expression of the MHV protein receptor mCEACAM, and furthermore, VLPs did not bind to mCEACAMexpressing cells that had been pretreated with neuraminidase ( Fig. 1F, right) . Together, these data suggest that, during MHV-JHM infection, the initial viral binding process is mediated by S-proteinϪsialic acid interactions, not by the protein receptor mCEACAM......
Document: Surprisingly, VLP binding to cells was not increased by expression of the MHV protein receptor mCEACAM, and furthermore, VLPs did not bind to mCEACAMexpressing cells that had been pretreated with neuraminidase ( Fig. 1F, right) . Together, these data suggest that, during MHV-JHM infection, the initial viral binding process is mediated by S-proteinϪsialic acid interactions, not by the protein receptor mCEACAM.
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