Author: Patton, John B.; Bennuru, Sasisekhar; Eberhard, Mark L.; Hess, Jessica A.; Torigian, April; Lustigman, Sara; Nutman, Thomas B.; Abraham, David
Title: Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum Document date: 2018_12_12
ID: 0yh5k6jk_62
Snippet: In conclusion, novel small-animal hosts, NSG mice, have been identified that support the survival and development of O. volvulus L3 into advanced L4 mammalian stages. Humanized mice have also been shown to be effective at identifying biomarkers for early O. volvulus infections. It is anticipated that these small-animal hosts for O. volvulus will also be useful as part of the effort to identify new anthelminthic drugs. Finally, the fact that O. vo.....
Document: In conclusion, novel small-animal hosts, NSG mice, have been identified that support the survival and development of O. volvulus L3 into advanced L4 mammalian stages. Humanized mice have also been shown to be effective at identifying biomarkers for early O. volvulus infections. It is anticipated that these small-animal hosts for O. volvulus will also be useful as part of the effort to identify new anthelminthic drugs. Finally, the fact that O. volvulus survives and develops in NSG mice humanized with human immune cells may provide the opportunity to study the human immune response to early infection with O. volvulus in a small animal model.
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