Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside Document date: 2016_9_20
ID: 04pp3lv0_62
Snippet: Current research work on RNAi therapy for COPD remains mainly in the in vitro stage, likely due to the insufficient understanding of the highly complex mechanisms underlying the pathology of the disease [120] . Moreover, the degree of airway inflammatory response is determined both by genetic and epigenetic factors. Since multiple inflammatory mediators are involved in the disease process, blocking a single type of molecule is unlikely to exert s.....
Document: Current research work on RNAi therapy for COPD remains mainly in the in vitro stage, likely due to the insufficient understanding of the highly complex mechanisms underlying the pathology of the disease [120] . Moreover, the degree of airway inflammatory response is determined both by genetic and epigenetic factors. Since multiple inflammatory mediators are involved in the disease process, blocking a single type of molecule is unlikely to exert significant clinical impact [206] . miRNA has the advantage of targeting multiple genes simultaneously. It is involved in the regulation of the inflammatory process of COPD by modulating the transcription and translation of genes. Differentiated expression of several miRNAs, like let-7c, miR-125b, miR-15b [210] and miR-199a-5p [211] were identified in COPD patients compared to subjects without COPD. Modulation the expression of multiple genes using miRNA could be a direction of RNAi therapy for the treatment of COPD.
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