Author: Van Nguyen, Dung; Van Nguyen, Cuong; Bonsall, David; Ngo, Tue Tri; Carrique-Mas, Juan; Pham, Anh Hong; Bryant, Juliet E.; Thwaites, Guy; Baker, Stephen; Woolhouse, Mark; Simmonds, Peter
Title: Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam Document date: 2018_2_28
ID: 0jtfc271_2
Snippet: HBV, HCV, and HEV are members of virus families Hepadnaviridae, Flaviviridae, and Hepeviridae, respectively. HBV has a partially double-stranded DNA genome with 4 overlapping open reading frames (ORFs) [3] , whereas HCV and HEV have a single-stranded RNA genome [4, 5] . While the origins of these human viruses are unknown, rodents and bats are putative reservoir hosts because they host a diverse array of Hepadnaviridae [6] [7] [8] , Hepeviridae [.....
Document: HBV, HCV, and HEV are members of virus families Hepadnaviridae, Flaviviridae, and Hepeviridae, respectively. HBV has a partially double-stranded DNA genome with 4 overlapping open reading frames (ORFs) [3] , whereas HCV and HEV have a single-stranded RNA genome [4, 5] . While the origins of these human viruses are unknown, rodents and bats are putative reservoir hosts because they host a diverse array of Hepadnaviridae [6] [7] [8] , Hepeviridae [7, [9] [10] [11] [12] [13] [14] [15] [16] , and genera Pegivirus [17] [18] [19] and Hepacivirus [17, 19, 20] of the Flaviviridae family including homologues of the human hepatitis viruses under question. Among these, it is of concern that a bat hepadnavirus may possess the ability to infect human liver cells [6] .
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