Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside Document date: 2016_9_20
ID: 04pp3lv0_42
Snippet: Seasonal influenza viruses, especially influenza type A virus, cause annual epidemics that led to millions of death worldwide [142] . It is one of the major public health problems. Two categories of antiviral drugs are currently approved to treat influenza, including M 2 ion-channel protein inhibitors (adamantanes) and neuraminidase inhibitors (zanamivir and oseltamivir). However, some influenza A virus strains have shown to be resistant to these.....
Document: Seasonal influenza viruses, especially influenza type A virus, cause annual epidemics that led to millions of death worldwide [142] . It is one of the major public health problems. Two categories of antiviral drugs are currently approved to treat influenza, including M 2 ion-channel protein inhibitors (adamantanes) and neuraminidase inhibitors (zanamivir and oseltamivir). However, some influenza A virus strains have shown to be resistant to these drugs [143, 144] , making the development of new antiviral drug urgently needed. A number of studies were carried out to investigate the use of RNAi to inhibit viral gene expression and protect cells from influenza infection. The most commonly investigated targets are the nucleocapsid protein (NP), polymerase acidic protein (PA) and polymerase basic protein (PB). These proteins are indispensable to influenza viral replication. More importantly, they are highly conserved across different subtypes of influenza virus strains [132] .
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