Author: Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea
Title: Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers Document date: 2019_12_25
ID: 034w5afv_44
Snippet: In a recent review Zaworotko and coworkers enlisted a total of eight commercially available pharmaceutical cocrystals [50] , showing that cocrystalline solid forms of current APIs are adequate for the fabrication of medicines for various types of therapies. At the same time, in the last few years the number of publications and patents related to pharmaceutical cocrystals has been increasing [50, 51] . Nevertheless, there are still several challen.....
Document: In a recent review Zaworotko and coworkers enlisted a total of eight commercially available pharmaceutical cocrystals [50] , showing that cocrystalline solid forms of current APIs are adequate for the fabrication of medicines for various types of therapies. At the same time, in the last few years the number of publications and patents related to pharmaceutical cocrystals has been increasing [50, 51] . Nevertheless, there are still several challenges for the development of cocrystals in pharmaceutical solid dosage forms, particularly in controlling the behavior of cocrystal dissolution, drug supersaturation and precipitation kinetics, which can be achieved by selecting suitable excipients that will delay nucleation and/or crystallization, and maintain adequate drug supersaturation levels [13, 51] .
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