Author: Kang, Hee; Park, Sung-Hyun; Yun, Jeong-Moon; Nam, Tae-Gyu; Kim, Young-Eun; Kim, Dae-Ok; Kim, Youn Jung
Title: Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity Document date: 2014_3_7
ID: 0bqhbm9p_31
Snippet: Since an elevated uptake of modified LDL is characteristic of monocyte differentiation [17] , we measured whether CWE may influence the activity of scavenger receptors in differentiating THP-1 cells. Cells were stimulated for 24 h with PMA in the presence of CWE and then incubated with Alexa 488 -acetyl LDL for 16 h. CWE suppressed Alexa 488 -acetyl LDL uptake in a concentration-dependent manner by 47%, 67% and 75% at 10, 50 and 100 μg/ml CWE, r.....
Document: Since an elevated uptake of modified LDL is characteristic of monocyte differentiation [17] , we measured whether CWE may influence the activity of scavenger receptors in differentiating THP-1 cells. Cells were stimulated for 24 h with PMA in the presence of CWE and then incubated with Alexa 488 -acetyl LDL for 16 h. CWE suppressed Alexa 488 -acetyl LDL uptake in a concentration-dependent manner by 47%, 67% and 75% at 10, 50 and 100 μg/ml CWE, respectively ( Figures 3E-G) . CWE also exerted a similar inhibition in primary macrophage culture: Alexa 488 -acLDL uptake was reduced by 40%, 45% and 55% at 10, 50 and 100 μg/ml CWE, respectively ( Figures 3H-J) .
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