Author: Chiramel, Abhilash I.; Brady, Nathan R.; Bartenschlager, Ralf
Title: Divergent Roles of Autophagy in Virus Infection Document date: 2013_1_25
ID: 1oawya1p_37
Snippet: More recently, Sir et al proposed a direct role of autophagy in serving as platforms for viral RNA replication [79] . In this study, the authors describe the localization of HCV replicase proteins NS5A and NS5B as well as nascent HCV RNA to autophagosome-like structures. However, these data are in direct opposition to studies showing that HCV proteins do not colocalize with autophagosomes in infected cells [23, 49, 80] . Thus, although autophagy .....
Document: More recently, Sir et al proposed a direct role of autophagy in serving as platforms for viral RNA replication [79] . In this study, the authors describe the localization of HCV replicase proteins NS5A and NS5B as well as nascent HCV RNA to autophagosome-like structures. However, these data are in direct opposition to studies showing that HCV proteins do not colocalize with autophagosomes in infected cells [23, 49, 80] . Thus, although autophagy is required for HCV replication, the precise role of autophagy or autophagy-related proteins in viral replication remains to be determined.
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