Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea

Supplementary Materials: The following data are available online at http://www.mdpi.com/1999-4923/12/1/23/s1: Table S1 . General characteristics of polymers used. Figure S1 . Scheme of the solvent-shift methodology employed to select polymers that delay nucleation and/or API crystallization. Figure S2 . The UV-vis quantification method was specific for NTZ at 435 nm. At 2.97 µg/mL of pure NTZ and both cocrystals, there is no interference by coformers in the quantification method used herein. At other concentration levels of NTZ and coformers, the observation was the same, there was no interference in NTZ quantitation by the coformers presence. Figure S3 . UV-vis spectra of samples from powders dissolution of NTZ (left) and NTZ-SUC cocrystal (right) formulated at different concentrations of Methocel ® 60 HG. NTZ spectrum did not change in presence of polymer. Figure S4 . Figure S5 . SEM images of the solid starting materials used for the powder dissolution tests: (a) NTZ, (b) physical mixture of NTZ and SUC; and solid residues recovered after the dissolution tests of the solids formulated with Methocel ® 60 HG: (c) NTZ with 1.0% w/w, (d) physical mixture of NTZ and SUC with 1.0% w/w, (e) NTZ with 5.0% w/w, (f) physical mixture of NTZ and SUC with 5.0% w/w. Note: The SEM images of the starting materials are presented at higher resolution than the remaining images (see scale in each image).