Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea

Nitazoxanide was kindly donated by Laboratories Senosiain, S.A de C.V., CDMX, México. Glutaric acid, succinic acid, hydroxypropyl methylcellulose (HPMC, MW: 26 kDa. This product has a methoxyl content of 19-24% and a hydroxypropoxyl content of 7-12%, viscosity 80-120 cP, 2% in H 2 O at 20 • C), methylcellulose (Methocel ® 60 HG and Methocel ® MC), hydroxypropyl cellulose (HPC 80,000 and HPC 370,000), polyvinylpyrrolidone (Kollidon ® 25), polyethylene glycol (Kollisolv ® ) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (Kolliphor ® P 407) were purchased from Sigma-Aldrich (St. Louis, MO, USA) as reagents for use only in the laboratory. All organic solvents used were purchased from J. T. Baker Chemical Co. (Phillipsburg, NJ, USA). Solvents and chemical compounds were used as received without further purification.