Author: Thomas, Joseph T.; Chen, Qi; Gauger, Phillip C.; Giménez-Lirola, Luis G.; Sinha, Avanti; Harmon, Karen M.; Madson, Darin M.; Burrough, Eric R.; Magstadt, Drew R.; Salzbrenner, Holly M.; Welch, Michael W.; Yoon, Kyoung-Jin; Zimmerman, Jeffrey J.; Zhang, Jianqiang
Title: Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs Document date: 2015_10_6
ID: 1kjk404o_51
Snippet: Success rate of PEDV isolation in cell culture has been low. Currently swine bioassay has remained the most reliable means to determine if infectious PEDV is present in a sample. Data from this study suggests a neonatal pig bioassay is more sensitive than a weaned pig bioassay to assess PEDV infectivity. Regarding duration of the swine bioassay, we observed that one pig (ID 9) in group 6 of the 5-day-old pig study did not shed virus in rectal swa.....
Document: Success rate of PEDV isolation in cell culture has been low. Currently swine bioassay has remained the most reliable means to determine if infectious PEDV is present in a sample. Data from this study suggests a neonatal pig bioassay is more sensitive than a weaned pig bioassay to assess PEDV infectivity. Regarding duration of the swine bioassay, we observed that one pig (ID 9) in group 6 of the 5-day-old pig study did not shed virus in rectal swabs until 3 DPI; thus 2-day duration of pig bioassay may not be sufficient to evaluate the infection outcome. We propose that 7-day duration would be considered appropriate for PEDV swine bioassay.
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