Author: Murdaca, Giuseppe; Tonacci, Alessandro; Negrini, Simone; Greco, Monica; Borro, Matteo; Puppo, Francesco; Gangemi, Sebastiano
Title: Effects of AntagomiRs on Different Lung Diseases in Human, Cellular, and Animal Models Document date: 2019_8_13
ID: 1rmwwjgi_27
Snippet: In this category, acute lung injury and pulmonary inflammation were included. Overall, eight articles were included, four each for the two conditions above mentioned. No studies on human subjects were retrieved, while works dealing with animal models and cell lines were relatively numerous. As in other sub-groups and possibly due to the slight heterogeneity of the clinical conditions included in this category, just one miRNA was studied in more t.....
Document: In this category, acute lung injury and pulmonary inflammation were included. Overall, eight articles were included, four each for the two conditions above mentioned. No studies on human subjects were retrieved, while works dealing with animal models and cell lines were relatively numerous. As in other sub-groups and possibly due to the slight heterogeneity of the clinical conditions included in this category, just one miRNA was studied in more than one article even if taken into account in two studies by the same research team (miR-374a, investigated in Adyshev et al., [80, 81] ). Summarizing the results, even in this group of conditions, antagomiRs were extremely useful in improving the outcome both in vivo and in vitro, with no report of lack of efficacy in any of the studies retrieved.
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