Author: Thomas, Joseph T.; Chen, Qi; Gauger, Phillip C.; Giménez-Lirola, Luis G.; Sinha, Avanti; Harmon, Karen M.; Madson, Darin M.; Burrough, Eric R.; Magstadt, Drew R.; Salzbrenner, Holly M.; Welch, Michael W.; Yoon, Kyoung-Jin; Zimmerman, Jeffrey J.; Zhang, Jianqiang
Title: Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs Document date: 2015_10_6
ID: 1kjk404o_39
Snippet: All four 5-day-old piglets in the groups 1 to 5 (inoculated with virus dilutions 10 −3 to 10 −7 ) and one pig (pig ID 9) in group 6 (inoculated with virus dilution 10 −8 ) developed mild to watery diarrhea at 1 DPI and diarrhea lasted through the study period. Dehydration and lethargy were also observed in these piglets at 2 DPI through the end of the study period. Vomiting was only observed in piglets inoculated with the 10 −3 dilution (.....
Document: All four 5-day-old piglets in the groups 1 to 5 (inoculated with virus dilutions 10 −3 to 10 −7 ) and one pig (pig ID 9) in group 6 (inoculated with virus dilution 10 −8 ) developed mild to watery diarrhea at 1 DPI and diarrhea lasted through the study period. Dehydration and lethargy were also observed in these piglets at 2 DPI through the end of the study period. Vomiting was only observed in piglets inoculated with the 10 −3 dilution (5.62×10 2 TCID 50 /ml, 10ml/pig) at 1 DPI. Due to severity of clinical signs, these piglets were euthanized and necropsied at 4 DPI. In contrast, 3 pigs (pig IDs 23, 13 and 8) in the group 6 inoculated with virus dilution 10 −8 and all 4 pigs in the negative control group remained active and clinically unaffected throughout the 7-day study period.
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