Selected article for: "activation induction and adaptive immune response"
Author: Chiramel, Abhilash I.; Brady, Nathan R.; Bartenschlager, Ralf
Title: Divergent Roles of Autophagy in Virus Infection
  • Document date: 2013_1_25
    • ID: 1oawya1p_25
    Snippet: The role of autophagy in delivering viral PAMPs to TLRs and the subsequent induction of autophagy upon TLR activation indicates the existence of a positive feedback loop. This feedback loop might not only play an important role in the autophagic sequestration and delivery of PAMPs to endosomal compartments, but also serve for autolysosomal degradation of virions and viral proteins, as well as for antigen presentation via MHC-I and MHC-II molecule.....
    Document: The role of autophagy in delivering viral PAMPs to TLRs and the subsequent induction of autophagy upon TLR activation indicates the existence of a positive feedback loop. This feedback loop might not only play an important role in the autophagic sequestration and delivery of PAMPs to endosomal compartments, but also serve for autolysosomal degradation of virions and viral proteins, as well as for antigen presentation via MHC-I and MHC-II molecules, thereby triggering the adaptive immune response.

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