Author: Hayward, Joshua A; Tachedjian, Mary; Cui, Jie; Cheng, Adam Z; Johnson, Adam; Baker, Michelle L; Harris, Reuben S; Wang, Lin-Fa; Tachedjian, Gilda
Title: Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity Document date: 2018_3_29
ID: 1i6c0l3e_23
Snippet: This study represents the first report of the differential evolution of an important antiviral gene family in bats relative to other mammals. The full account and explanation of the ability of bats to act as such effective hosts and transmitters of zoonotic viral pathogens will likely consist of many complex and interlinking factors beyond simple metrics such as gene numbers and amino acid sequence characteristics. Ongoing studies of this expande.....
Document: This study represents the first report of the differential evolution of an important antiviral gene family in bats relative to other mammals. The full account and explanation of the ability of bats to act as such effective hosts and transmitters of zoonotic viral pathogens will likely consist of many complex and interlinking factors beyond simple metrics such as gene numbers and amino acid sequence characteristics. Ongoing studies of this expanded gene family should further demystify the strategies and mechanisms utilized by bats that result in an impressive tolerance for viral infections.
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