Author: Laneve, Pietro; Piacentini, Lucia; Casale, Assunta Maria; Capauto, Davide; Gioia, Ubaldo; Cappucci, Ugo; Di Carlo, Valerio; Bozzoni, Irene; Di Micco, Patrizio; Morea, Veronica; Di Franco, Carmela Antonia; Caffarelli, Elisa
Title: Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration Document date: 2017_1_31
ID: 1rw05x6m_3
Snippet: The same conservation pattern shown in Fig. 1b is also observed in a multiple sequence alignment extended to over 700 XendoU homologs (Supplementary Table 1 ). Here, the three XendoU residues whose point mutation abolished catalysis (i.e., H162, H178, K224) are 100% conserved, most of the other residues whose mutation affects catalysis being conserved in > 90% of the sequences (see Fig. 1b and Supplementary Table 1) 2 . Conversely, in the 251-292.....
Document: The same conservation pattern shown in Fig. 1b is also observed in a multiple sequence alignment extended to over 700 XendoU homologs (Supplementary Table 1 ). Here, the three XendoU residues whose point mutation abolished catalysis (i.e., H162, H178, K224) are 100% conserved, most of the other residues whose mutation affects catalysis being conserved in > 90% of the sequences (see Fig. 1b and Supplementary Table 1) 2 . Conversely, in the 251-292 variable region, only two of the RNA binding residues are conserved in > 50% of the homologous sequences.
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