Selected article for: "antiviral innate immune response and Î production"
Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells
  • Document date: 2017_2_1
    • ID: 1ljye9pj_4
    Snippet: However, the effects of DOX on pig intestinal epithelial cells are equivocal, and questions about whether DOX induces mitophagy in these cells remain unanswered. In this study, we evaluated the effects of DOX on the IPEC-J2 cell line, as an in vitro model of swine small intestine epithelium. We first found that DOX induced mitophagy rather than apoptosis in this cell line. Moreover, DOX decreased IFN-β production in IPEC-J2 cells transfected wit.....
    Document: However, the effects of DOX on pig intestinal epithelial cells are equivocal, and questions about whether DOX induces mitophagy in these cells remain unanswered. In this study, we evaluated the effects of DOX on the IPEC-J2 cell line, as an in vitro model of swine small intestine epithelium. We first found that DOX induced mitophagy rather than apoptosis in this cell line. Moreover, DOX decreased IFN-β production in IPEC-J2 cells transfected with poly (I: C). These findings suggest that use of DOX in the pig industry sabotages the antiviral innate immune response of swine intestinal epithelial cells.

    Search related documents:
    Co phrase search for related documents
    • apoptosis mitophagy and DOX mitophagy induce: 1
    • apoptosis mitophagy and mitophagy induce: 1, 2
    • apoptosis mitophagy induce and DOX apoptosis mitophagy induce: 1
    • apoptosis mitophagy induce and DOX mitophagy induce: 1
    • apoptosis mitophagy induce and mitophagy induce: 1, 2
    • cell line and DOX effect: 1, 2
    • cell line and epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell line and IFN β production: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • cell line and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell line and intestinal epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell line and pig industry: 1, 2, 3
    • cell line and pig intestinal epithelial cell: 1
    • DOX apoptosis mitophagy induce and mitophagy induce: 1
    • DOX effect and immune response: 1, 2
    • DOX effect and mitophagy induce: 1
    • DOX mitophagy induce and mitophagy induce: 1, 2
    • epithelial cell and IFN β production: 1, 2, 3, 4, 5, 6, 7, 8
    • epithelial cell and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • epithelial cell and intestinal epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25