Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells Document date: 2017_2_1
ID: 1ljye9pj_4
Snippet: However, the effects of DOX on pig intestinal epithelial cells are equivocal, and questions about whether DOX induces mitophagy in these cells remain unanswered. In this study, we evaluated the effects of DOX on the IPEC-J2 cell line, as an in vitro model of swine small intestine epithelium. We first found that DOX induced mitophagy rather than apoptosis in this cell line. Moreover, DOX decreased IFN-β production in IPEC-J2 cells transfected wit.....
Document: However, the effects of DOX on pig intestinal epithelial cells are equivocal, and questions about whether DOX induces mitophagy in these cells remain unanswered. In this study, we evaluated the effects of DOX on the IPEC-J2 cell line, as an in vitro model of swine small intestine epithelium. We first found that DOX induced mitophagy rather than apoptosis in this cell line. Moreover, DOX decreased IFN-β production in IPEC-J2 cells transfected with poly (I: C). These findings suggest that use of DOX in the pig industry sabotages the antiviral innate immune response of swine intestinal epithelial cells.
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