Author: Qing, Enya; Hantak, Michael; Perlman, Stanley; Gallagher, Tom
Title: Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection Document date: 2020_2_11
ID: 1mowsbjy_4
Snippet: VLPs, either with or without JHM or A59 S proteins, were applied to mCEACAMnegative HeLa cells at equivalent (Rluc) multiplicities. Under these conditions, the S-protein levels on the A59 VLPs exceeded those of JHM VLPs (Fig. 1D ). Yet, in agreement with the hemagglutinating effects of the viruses, the JHM S proteins increased VLP-HeLa cell binding above background levels, while the A59 S proteins did not (Fig. 1E) . Notably, the JHM VLPs did not.....
Document: VLPs, either with or without JHM or A59 S proteins, were applied to mCEACAMnegative HeLa cells at equivalent (Rluc) multiplicities. Under these conditions, the S-protein levels on the A59 VLPs exceeded those of JHM VLPs (Fig. 1D ). Yet, in agreement with the hemagglutinating effects of the viruses, the JHM S proteins increased VLP-HeLa cell binding above background levels, while the A59 S proteins did not (Fig. 1E) . Notably, the JHM VLPs did not bind to HeLa cells that were pretreated with neuraminidase ( Fig. 1F, left) , suggesting that the VLP binding was dependent on cellular sialic acids.
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