Author: Thomas, Joseph T.; Chen, Qi; Gauger, Phillip C.; Giménez-Lirola, Luis G.; Sinha, Avanti; Harmon, Karen M.; Madson, Darin M.; Burrough, Eric R.; Magstadt, Drew R.; Salzbrenner, Holly M.; Welch, Michael W.; Yoon, Kyoung-Jin; Zimmerman, Jeffrey J.; Zhang, Jianqiang
Title: Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs Document date: 2015_10_6
ID: 1kjk404o_45
Snippet: For pigs necropsied at 7 DPI, microscopic lesions consistent with viral infection were observed in 2/3 pigs of group 1 (10 −3 dilution), 1/3 pigs of group 2 (10 −4 dilution), 1/3 pigs of group 3 (10 −5 dilution), and 0/3 pigs of groups 4-7 (10 −6 to 10 −8 dilutions and negative control); IHC staining results were consistent with the presence or absence of microscopic lesions. However, villus heights, crypt depths, villus/crypt ratios of.....
Document: For pigs necropsied at 7 DPI, microscopic lesions consistent with viral infection were observed in 2/3 pigs of group 1 (10 −3 dilution), 1/3 pigs of group 2 (10 −4 dilution), 1/3 pigs of group 3 (10 −5 dilution), and 0/3 pigs of groups 4-7 (10 −6 to 10 −8 dilutions and negative control); IHC staining results were consistent with the presence or absence of microscopic lesions. However, villus heights, crypt depths, villus/crypt ratios of pigs in all groups 1-7 were not significantly different from each other at 7 DPI (data not shown). For pigs necropsied at 28 DPI, no microscopic lesions or IHC staining were observed in any pigs of groups 1-7.
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