Author: Murdaca, Giuseppe; Tonacci, Alessandro; Negrini, Simone; Greco, Monica; Borro, Matteo; Puppo, Francesco; Gangemi, Sebastiano
Title: Effects of AntagomiRs on Different Lung Diseases in Human, Cellular, and Animal Models Document date: 2019_8_13
ID: 1rmwwjgi_15
Snippet: Six studies were published on animal models, of which three investigated asthma, and one each COPD, airway disease, and airway hyper-responsiveness. All those studies took into account mice models, with miR-21 that was investigated in three out of the six works. Overall, the results were encouraging, with minor differences. Indeed, as observed by Collison et al. [24] , just the inhibition of miR-145, but not miR-21 or let-7b, inhibited eosinophil.....
Document: Six studies were published on animal models, of which three investigated asthma, and one each COPD, airway disease, and airway hyper-responsiveness. All those studies took into account mice models, with miR-21 that was investigated in three out of the six works. Overall, the results were encouraging, with minor differences. Indeed, as observed by Collison et al. [24] , just the inhibition of miR-145, but not miR-21 or let-7b, inhibited eosinophilic inflammation, mucus hypersecretion, TH2 cytokine production, and airway hyper-responsiveness, and also Plank et al. [30] on asthma observed that the use of the respective antagomiR (anti-miR-155-5p) reduced miR-155-5p expression, but failed to alter the disease phenotype.
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