Selected article for: "medium time period and time period"
Author: Salas-Zúñiga, Reynaldo; Rodríguez-Ruiz, Christian; Höpfl, Herbert; Morales-Rojas, Hugo; Sánchez-Guadarrama, Obdulia; Rodríguez-Cuamatzi, Patricia; Herrera-Ruiz, Dea
Title: Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers
  • Document date: 2019_12_25
    • ID: 034w5afv_53
    Snippet: Despite the inclusion of polymer, the NTZ-SUC cocrystals were transformed fast into pure NTZ, as revealed by PXRD patterns of solid residues recovered after the dissolution tests ( Figure 8) . However, the SEM analysis reveals that methylcellulose affects significantly the particle size and morphology of NTZ ( Figure 9 ). The polymer-NTZ interactions probably influence the nucleation process and subsequent crystal growth/agglomeration, thus givin.....
    Document: Despite the inclusion of polymer, the NTZ-SUC cocrystals were transformed fast into pure NTZ, as revealed by PXRD patterns of solid residues recovered after the dissolution tests ( Figure 8) . However, the SEM analysis reveals that methylcellulose affects significantly the particle size and morphology of NTZ ( Figure 9 ). The polymer-NTZ interactions probably influence the nucleation process and subsequent crystal growth/agglomeration, thus giving high drug concentration in the dissolution medium over a prolonged time period. Although NTZ-polymer interactions are expected to operate also for the formulations with pure NTZ and the physical mixture, these formulations lack the advantageous initial and immediate dissolution increase of the cocrystal components driven by favorable coformer solubilization.

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