Author: Qing, Enya; Hantak, Michael; Perlman, Stanley; Gallagher, Tom
Title: Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection Document date: 2020_2_11
ID: 1mowsbjy_3
Snippet: We noted that MHV VLPs incorporated intact JHM spike proteins at levels that were similar to authentic viruses. This was in contrast to JHM spikes that were incorporated into vesicular stomatitis virus (VSV)-based pseudoparticles, most of which were degraded (Fig. 1C) . These findings indicated that the VLPs structurally resemble authentic virus structures, at least with respect to spike stability and particle incorporation. As spike stability an.....
Document: We noted that MHV VLPs incorporated intact JHM spike proteins at levels that were similar to authentic viruses. This was in contrast to JHM spikes that were incorporated into vesicular stomatitis virus (VSV)-based pseudoparticles, most of which were degraded (Fig. 1C) . These findings indicated that the VLPs structurally resemble authentic virus structures, at least with respect to spike stability and particle incorporation. As spike stability and multivalent presentation are frequently required to detect sialate interactions (21, 41) , we considered the VLPs to be well-suited for receptor binding studies. Additionally, VLPs are equally produced either with or without incorporated S proteins (42) , making it possible to use VLPs in quantifying S-protein-dependent virus-cell binding processes.
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