Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells Document date: 2017_2_1
ID: 1ljye9pj_36
Snippet: Accumulating evidence suggests that mitophagy plays a pivotal role in the antiviral innate immune response by preserving cellular homeostasis under stress (Kroemer et al., 2010) ; as mitochondrial fission can inhibit RLR signaling (Castanier et al., 2010) , we assumed that DOX could diminish the production of the type I interferon of IPEC-J2 cells. To confirm our speculation, we examined the production of IFN-β of IPEC-J2 at the mRNA level. Cons.....
Document: Accumulating evidence suggests that mitophagy plays a pivotal role in the antiviral innate immune response by preserving cellular homeostasis under stress (Kroemer et al., 2010) ; as mitochondrial fission can inhibit RLR signaling (Castanier et al., 2010) , we assumed that DOX could diminish the production of the type I interferon of IPEC-J2 cells. To confirm our speculation, we examined the production of IFN-β of IPEC-J2 at the mRNA level. Consequently, following poly (I: C) transfection, the production of IFN-β was inhibited by DOX in a dose-dependent manner ( Figure 5A) .
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