Selected article for: "µg ml and DOX dose"
Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells
  • Document date: 2017_2_1
    • ID: 1ljye9pj_37
    Snippet: IPEC-J2 cells were pretreated with DOX at a concentration of 50 µg/ml for 24 h before poly (I: C) stimulation, and this significantly reduced poly (I: C)-induced IFN at indicated times ( Figure 5B) . Moreover, we measured the expression of two interferon-stimulation genes (ISGs) at the mRNA level. Similar to the result for IFN-β, the expression levels of IFIT1 ( Figure 5C ) and DDX58 ( Figure 5D ) mRNAs were suppressed by DOX in a dose-dependen.....
    Document: IPEC-J2 cells were pretreated with DOX at a concentration of 50 µg/ml for 24 h before poly (I: C) stimulation, and this significantly reduced poly (I: C)-induced IFN at indicated times ( Figure 5B) . Moreover, we measured the expression of two interferon-stimulation genes (ISGs) at the mRNA level. Similar to the result for IFN-β, the expression levels of IFIT1 ( Figure 5C ) and DDX58 ( Figure 5D ) mRNAs were suppressed by DOX in a dose-dependent manner. Based on these data, we concluded that DOX had a negative effect on RIG-I-like receptor (RLR) signaling in IPEC-J2 cells.

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