Author: Xing, Yang; Liqi, Zhu; Jian, Lin; Qinghua, Yu; Qian, Yang
Title: Doxycycline Induces Mitophagy and Suppresses Production of Interferon-ß in IPEC-J2 Cells Document date: 2017_2_1
ID: 1ljye9pj_39
Snippet: We introduced transmissible gastroenteritis virus (TGEV), an Alphacoronavirus that causes clinical watery diarrhea, dehydration, and vomiting, to piglets <2 weeks old to elucidate whether DOX contributes to replication of TGEV by suppressing IFN-β. The TGEV titers were quantified using a viral plaque assay after 24 h of TGEV infection in DOX-pretreated IPEC-J2 cells. The viral plaque formation clearly showed that DOX increased TGEV replication s.....
Document: We introduced transmissible gastroenteritis virus (TGEV), an Alphacoronavirus that causes clinical watery diarrhea, dehydration, and vomiting, to piglets <2 weeks old to elucidate whether DOX contributes to replication of TGEV by suppressing IFN-β. The TGEV titers were quantified using a viral plaque assay after 24 h of TGEV infection in DOX-pretreated IPEC-J2 cells. The viral plaque formation clearly showed that DOX increased TGEV replication significantly (Figures 6A,B) . Upon the infection of cells exposed to DOX, TGEV titers were also quantified by TCID50 DOX pretreatment increased the viral progeny yield in TGEV-infected IPEC-J2 cells ( Figure 6C) . DOX clearly suppressed the antiviral innate immunity of IPEC-J2 cells and facilitated the replication of TGEV in IPEC-J2 cells.
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