Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study Document date: 2019_12_19
ID: 15e043uf_35
Snippet: Airway hyper-responsiveness AZD8848 attenuated the methacholine-induced AHR compared with placebo after the allergen challenge performed 1 week after the last dose (treatment ratio: 2.20 (95% CI: 1.12, 4.33) p = 0.024). No effect was observed with AZD8848 on the pre-allergen methacholine challenge at 1 week after the last dose. There was no effect of AZD8848 on AHR at week 4 after the last dose. Maximum AEs/patient 8 9 9.....
Document: Airway hyper-responsiveness AZD8848 attenuated the methacholine-induced AHR compared with placebo after the allergen challenge performed 1 week after the last dose (treatment ratio: 2.20 (95% CI: 1.12, 4.33) p = 0.024). No effect was observed with AZD8848 on the pre-allergen methacholine challenge at 1 week after the last dose. There was no effect of AZD8848 on AHR at week 4 after the last dose. Maximum AEs/patient 8 9 9
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