Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection Document date: 2020_1_20
ID: 0zr2e8lh_23
Snippet: These molecular initiatives and their corresponding downstream effects are collectively known as the unfolded protein response (UPR). This evolutionarily conserved countermeasure induces pro-survival responses including global arrest of protein synthesis, upregulation of protein degradation factors, and enhanced protein folding capability [45] . However, under severe ER stress conditions, UPR will instead trigger apoptosis......
Document: These molecular initiatives and their corresponding downstream effects are collectively known as the unfolded protein response (UPR). This evolutionarily conserved countermeasure induces pro-survival responses including global arrest of protein synthesis, upregulation of protein degradation factors, and enhanced protein folding capability [45] . However, under severe ER stress conditions, UPR will instead trigger apoptosis.
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