Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection Document date: 2020_1_20
ID: 0zr2e8lh_16
Snippet: Moreover, ZIKV-infected Huh7 cells also exhibited a unique structural alteration of collapsed ER cisterna or more commonly known as zippered ER (zER) (Fig. 1 ) that reminisce the observation reported in avian infectious bronchitis virus (IBV) infection, a (+)-ssRNA virus from the Coronaviridae family [32, 40] . This finding presents the first identification of such structure among flavivirus-infected cells and has only been observed in ZIKV-infec.....
Document: Moreover, ZIKV-infected Huh7 cells also exhibited a unique structural alteration of collapsed ER cisterna or more commonly known as zippered ER (zER) (Fig. 1 ) that reminisce the observation reported in avian infectious bronchitis virus (IBV) infection, a (+)-ssRNA virus from the Coronaviridae family [32, 40] . This finding presents the first identification of such structure among flavivirus-infected cells and has only been observed in ZIKV-infected Huh7 cells, suggesting that cell-typespecific factors are possibly required to generate this structure [32] . The role of zER in ZIKV infection is unclear; however, zER are frequently found adjacent to VPs suggestive of functions associated with vesicles formation, which is consistent with observations made in IBVinfected cells [32, 40] . Nonetheless, this unique finding warrants further research to elucidate the mechanistic details and biological relevance of the zER.
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