Selected article for: "ER stress and misfolded unfolded protein"
Author: Mohd Ropidi, Muhammad Izzuddin; Khazali, Ahmad Suhail; Nor Rashid, Nurshamimi; Yusof, Rohana
Title: Endoplasmic reticulum: a focal point of Zika virus infection
  • Document date: 2020_1_20
    • ID: 0zr2e8lh_33
    Snippet: Previous study reported that ectopic expression of XBP1 promotes expansion of the ER, a visual sign often manifested in response to ER stress [66] . This morphological change is hypothesized to reduce the local concentration of misfolded/unfolded proteins and accommodate the overwhelming demand for protein folding-a significant portion of which is neosynthesized viral polyproteins [47, 67] . Consistent with increased expression of XBP1, ultrastru.....
    Document: Previous study reported that ectopic expression of XBP1 promotes expansion of the ER, a visual sign often manifested in response to ER stress [66] . This morphological change is hypothesized to reduce the local concentration of misfolded/unfolded proteins and accommodate the overwhelming demand for protein folding-a significant portion of which is neosynthesized viral polyproteins [47, 67] . Consistent with increased expression of XBP1, ultrastructural characterization of ZIKV-infected cells reported significant ER enlargement extending across the cytoplasm and is related to ZIKV-induced ER stress [32, 35, 36, 47] .

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