Author: Leaker, Brian R.; Singh, Dave; Lindgren, Sam; Almqvist, Gun; Eriksson, Leif; Young, Barbara; O’Connor, Brian
Title: Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study Document date: 2019_12_19
ID: 15e043uf_23
Snippet: Sputum samples were induced at the first study visit before allergen challenge and again at the third study visit after allergen challenge, to provide baseline biomarker measurements, including eosinophils (Fig. 1) . Sputum induction was repeated at Visit 12 and Visit 15, after the last dose of AZD8848 but before allergen challenge, and again at Visits 14 and 17, after the last dose and following allergen challenge to provide information on the d.....
Document: Sputum samples were induced at the first study visit before allergen challenge and again at the third study visit after allergen challenge, to provide baseline biomarker measurements, including eosinophils (Fig. 1) . Sputum induction was repeated at Visit 12 and Visit 15, after the last dose of AZD8848 but before allergen challenge, and again at Visits 14 and 17, after the last dose and following allergen challenge to provide information on the duration of any observed effect of the study drug for 1 week and 4 weeks post-dosing. Sputum induction was performed 15 min after administration of 200 μg of salbutamol, with 5% hypertonic saline inhaled for 5 mins before each of three cycles of expectoration.
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