Author: Chiramel, Abhilash I.; Brady, Nathan R.; Bartenschlager, Ralf
Title: Divergent Roles of Autophagy in Virus Infection Document date: 2013_1_25
ID: 1oawya1p_42
Snippet: Upon infection of macrophages with HIV-1, the viral assembly protein Gag interacts with LC3-II, and this association allows the processing of the Gag subunit p24. Confocal microscopy and EM analyses revealed that gag-derived matrix (MA) protein p17 (a component of HIV-1 particles) colocalized with membrane compartments that stained positive for LC3 and that were in close proximity to the plasma membrane [28] (Figure 4) . These structures are simi.....
Document: Upon infection of macrophages with HIV-1, the viral assembly protein Gag interacts with LC3-II, and this association allows the processing of the Gag subunit p24. Confocal microscopy and EM analyses revealed that gag-derived matrix (MA) protein p17 (a component of HIV-1 particles) colocalized with membrane compartments that stained positive for LC3 and that were in close proximity to the plasma membrane [28] (Figure 4) . These structures are similar to those proposed previously as sites of HIV-1 assembly and budding in macrophages [28] . Furthermore, the ability of the HIV-1 Nef protein to inhibit autophagosome acidification was also shown to be required for release of infectious virions [28] . How acidification affects Gag-LC3 interaction still remains to be addressed.
Search related documents:
Co phrase search for related documents- assembly protein and confocal microscopy: 1, 2, 3, 4, 5, 6
- assembly protein and infectious virion: 1
- assembly protein and plasma membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- assembly protein and viral assembly protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- assembly site and close proximity: 1, 2, 3, 4
- assembly site and confocal microscopy: 1, 2, 3, 4, 5, 6
- assembly site and EM confocal microscopy: 1
- assembly site and EM confocal microscopy analysis: 1
- assembly site and membrane compartment: 1, 2
- assembly site and plasma membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- assembly site and viral assembly protein: 1, 2, 3, 4
- close proximity and confocal microscopy: 1, 2, 3, 4, 5, 6
- close proximity and EM confocal microscopy: 1
- close proximity and EM confocal microscopy analysis: 1
- close proximity and macrophage infection: 1
- close proximity and membrane compartment: 1
- close proximity and Nef protein: 1
- close proximity and plasma membrane: 1, 2, 3, 4, 5, 6
- close proximity and positive stain: 1
Co phrase search for related documents, hyperlinks ordered by date