Author: Chiramel, Abhilash I.; Brady, Nathan R.; Bartenschlager, Ralf
Title: Divergent Roles of Autophagy in Virus Infection Document date: 2013_1_25
ID: 1oawya1p_43
Snippet: Lastly, autophagy has been shown to serve in the non-lytic release of non-enveloped picornaviruses [18, 73] (Figure 4 ). Pharmacological inhibition of autophagy or silencing of expression of key autophagy factors results in a decrease in infectious particle production. Moreover, disrupting the microtubule network by using nocodazole treatment or challenging cells with a mutant virus resulted in increased mobility of poliovirus-induced GFP-LC3 str.....
Document: Lastly, autophagy has been shown to serve in the non-lytic release of non-enveloped picornaviruses [18, 73] (Figure 4 ). Pharmacological inhibition of autophagy or silencing of expression of key autophagy factors results in a decrease in infectious particle production. Moreover, disrupting the microtubule network by using nocodazole treatment or challenging cells with a mutant virus resulted in increased mobility of poliovirus-induced GFP-LC3 structures, concomitant with an increase of extracellular infectious particles [78] . Although the mechanism of this non-lytic virus release is not known, recent studies have confirmed the role of autophagy in the unconventional secretion of diverse substrates [89] .
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